最新的神經罕見疾病、腦神經退化相關

醫學期刊專文、疾病治療突破性研究成果

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｜全球罕見疾病研究

各國最近一年之神經罕見疾病研究

  1. Jinkuk Kim, et al. Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease Oct 09. DOI: 10.1056/NEJMoa1813279 Read More
  2. Rebeccah A. W, et al. Structure of amyloid-β (20-34) with Alzheimer’s-associated isomerization at Asp23 reveals a distinct protofilament interface., July 26, 2019. Read More
  3. Niklas Mattsson and Oskar Hansson. New PET Staging Scheme for Amyloid? July 25, 2019. Read more
  4. Sarah J. Tabrizi, et al. Targeting Huntingtin Expression in Patients with Huntington’s Disease., May 6, 2019., DOI: 10.1056/NEJMoa1900907. Read more
  5. Kenneth H. Fischbeck, M.D., and Nancy S. Wexler, Ph.D. Oligonucleotide Treatment for Huntington’s Disease., May 6, 2019., DOI: 10.1056/NEJMe1904861. Read more
  6. Atsushi Aoyagi, et al. Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain., Science Translational Medicine 01 May 2019: Vol. 11, Issue 490. Read more
  7. Joe Balintfy. Guidelines proposed for newly defined Alzheimer's-like brain disorder., April 30, 2019. Read more
  8. Christopher T, et al. A 60-Year-Old Man with Weakness and Difficulty Chewing., 18 April, 2019. Read more
  9. Andrea Cortese, et al. Biallelic expansion of an intronic repeat in RFC1 is a common cause of late-onset ataxia., Nature Genetics .volume 51, pages649–658, 29 March, 2019. Read more
  10. Blood test shows promise in predicting presymptomatic disease progression in people at risk of familial Alzheimer’s ., 2 April, 2019. Read more
  11. Preische O, et al. Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease., Nature Medicine. volume 25, pages 277-283, 2019. Read more
  12. 阿茲海默症早期篩檢現曙光！「神經絲輕鏈」透露先機？ , GENEONLINE , 23 January, 2019. Read more
  13. Athauda D, et al. Utility of neuronal-derived exosomes to examine molecular mechanisms that affect motor function in patients with Parkinson disease: A secondary analysis of the Exenatide-PD trial. , JAMA Neurology. 14 January, 2019 . Read more
  14. Vijaya Lyer. Gene Therapy Candidate AMT-130 Shows Promise in Preclinical Findings. , 7 March, 2019. Read more
  15. E.P. Moreno-Jiménez et al. Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease ., Nature Medicine. volume 25, pages 554–560, April 2019. Read more
  16. Oliver Preische, Stephanie A. Schultz, Anja Apel et al. Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease ., Nature Medicine. volume 25, pages 277–283, 21 January, 2019. Read more
  17. Daniel A. Nation, Melanie D. Sweeney, Axel Montagne. et al. Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction ., Nature Medicine. volume 25, pages 270–276 , 14 January, 2019. Read more

｜腦組織研究

  • Stuart Youngner and Insoo Hyun, Pig experiment challenges assumptions around brain damage in people, 17 April, 2019. Read More
  • Zvonimir Vrselja, et al, Restoration of brain circulation and cellular functions hours post-mortem, Nature Medicine. volume 568, pages 336–343, 17 April, 2019. Read more
  • Nita A. Farahany, et al, The ethics of experimenting with human brain tissue, Nature Medicine. volume 556, pages 429-432, 25 April , 2018. Read more

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「HD LEGACY」亨丁頓氏病遺贈計畫，終結HD痛苦延續

「美國亨丁頓氏病協會(HDSA)」及「治癒HD倡議基金會(CHDI Foundation)」共同宣布一項合作案，了解更多（ >>> )